Mahmoud joined Retro in June 2023, bringing extensive research experience from his PhD at Tel Aviv University and postdoctoral training at the Mckinney-Freeman Lab in St Jude Children’s Research Hospital. His research focuses on interactions between hematopoietic stem cells (HSCs) and the bone marrow microenvironment during development and in hematological diseases, particularly in multiple myeloma and sickle cell disease. Mahmoud’s significant achievement includes reversing the HSC dysfunction during aging in sickle cell disease through the rejuvenation of transcription factor activities in the bone marrow niche cells. At Retro, he is motivated to extend human lifespan by revitalizing HSCs and their microenvironment. Outside work, Mahmoud enjoys traveling, and spending time with friends, hiking with his dog, Leo, and unwinding with a good book or TV show.